Vielmetter Los Angeles was founded in 2000 to show artists diverse cultural backgrounds engaged in rigorously conceptual practices. The program is international in scope and represents an equal number of male and female artists. In 2010, the gallery expanded to Culver City to show ambitiously scaled museum-level exhibitions. In 2019, the gallery moved to its current 24,000 sq. ft. space in Downtown Los Angeles.
Many artists have been represented from the beginning of their careers. The gallery presented the first solo exhibitions of Rodney McMillian, Edgar Arceneaux, Ruben Ochoa, and Wangechi Mutu, as well as the first Los Angeles solo exhibitions of Amy Sillman and Mickalene Thomas. Vielmetter Los Angeles has developed the careers of Nicole Eisenman, Charles Gaines, Karl Haendel, and Andrea Bowers to their current levels of international importance.
Recent additions to the program include Genevieve Gaignard, Paul Mpagi Sepuya, Deborah Roberts, Sarah Cain and Louise Fishman.